Biological monitoring of occupational exposure to methyl ethyl ketone by means of urinalysis for methyl ethyl ketone itself
| Autor: | Michiko Miyasaka, Akio Koizumi, Kazuyuki Kurasako, Masayuki Ikeda, Miho Kumai, Kunihiko Sato, Takao Watanabe |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
chemistry.chemical_classification
Male Creatinine Air Pollutants Ketone Chromatography Chromatography Gas Time Factors Inhalation Urinalysis medicine.diagnostic_test Urine specific gravity Urinary system Public Health Environmental and Occupational Health Urine Air Pollutants Occupational Environmental Exposure Butanones Excretion chemistry.chemical_compound chemistry medicine Humans |
| Zdroj: | International archives of occupational and environmental health. 50(2) |
| ISSN: | 0340-0131 |
| Popis: | Head space gas chromatography (GC) was applied to measure methyl ethyl ketone (MEK) in urine from 62 MEK-exposed male workers, whose individual intensity of exposure to MEK was monitored utilizing the carbon felt dosimeter. The urinary MEK level increased rapidly to reach a plateau in the first quarter of the daily 8-h work, while very little MEK was detected in the preshift urine. When the MEK levels in the urine at the end of the shift were compared with the afternoon MEK-TWA values, the uncorrected MEK in urine correlated best with MEK in air (r = 0.774, n = 62), while correction for creatinine gave a comparable result and the correlation was poorer when corrected for a specific gravity of urine or for the lapse of time after preceding passage of urine. Balance of MEK absorption via inhalation and MEK excretion into urine revealed that only 0.1% of MEK absorbed will be excreted unchanged into urine. Wider application of head space GC is discussed for the analysis of unmetabolized solvents in urine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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