Ion Transport in the Cochlea of Guinea Pig:II. Chloride Transport
| Autor: | Philip E. Hamrick, Teruzo Konishi |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Endocochlear potential
Endolymph Guinea Pigs Action Potentials Perilymph Ouabain Guinea pig Oxygen Consumption fluids and secretions Chlorides otorhinolaryngologic diseases medicine Animals Hypoxia Cochlea Ion transporter Chemistry General Medicine Anatomy Cochlear Duct Scala Tympani Perfusion medicine.anatomical_structure Otorhinolaryngology Biophysics sense organs medicine.drug |
| Zdroj: | Acta Oto-Laryngologica. 86:176-184 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.3109/00016487809124734 |
| Popis: | The −CI transport across the endolymph-peri-lymph barrier in guinea pigs was studied by perfusing the perilymphatic space with artificial perilymph containing 36CI and measuring the uptake of 36CI in the endolymph. In normal animals no marked difference in −CI concentration was found between the endolymph and perilymph. The data showed that the uptake of 36CI in the endolymph could be represented by a simple exponential function of the perfusion time, the rate constant being 0.01 min−1. The concentration of 36CI in the endolymph was greater with perfusion of the scala vestibuli than with perfusion of the scala tympani, indicating that Reissner's membrane is more permeable to −CI than the rest of the endolymph-perilymph barrier. Anoxia and local application of ouabain decreased the −CI concentration and 36CI uptake in the endolymph. Our results imply that the endocochlear potential is the principal driving force for unidirectional flux of −CI from perilymph to endolymph. |
| Databáze: | OpenAIRE |
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