Silk sericin induced fabrication of reduced graphene oxide and its in-vitro cytotoxicity, photothermal evaluation
| Autor: | Jegatheeswaran Sonamuthu, Guobin Han, Sireesh Babu Maddinedi, Qing-Qing Ni, Juming Yao, Serap Suzuk Yildiz, Yurong Cai, Junkuo Gao |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility Cell Survival Infrared Rays Silk Biophysics Oxide Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Sericin Cell Line law.invention chemistry.chemical_compound Microscopy Electron Transmission law Humans Radiology Nuclear Medicine and imaging Sericins Cytotoxicity Radiation Radiological and Ultrasound Technology Graphene Photoelectron Spectroscopy Oxides Hyperthermia Induced Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences SILK chemistry Nanomedicine Graphite 0210 nano-technology HeLa Cells |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 186:189-196 |
| ISSN: | 1011-1344 |
| DOI: | 10.1016/j.jphotobiol.2018.07.020 |
| Popis: | Nowadays, photothermal agents have attained considerable attention in nanomedicine for the treatment of cancer after chemotherapy, surgery, biological therapy and radiotherapy. In this work, we showed a sericin-based, simple approach for synthesis of sericin functionalized reduced graphene oxide (SRGO) with low cytotoxicity and photo thermal efficiency. During the synthesis, the GO is deoxygenated in situ and functionalized by sericin, a low-cost, silk protein and concurrently forms SRGO. The subsequent SRGO disperse well in water with higher biocompatibility because of the decoration of sericin on graphene sheets. The prepared SRGO exhibited a good photothermal capacity with near-infrared laser irradiation (808 nm) for efficient killing of HeLa cells. Further, the synthesized SRGO could act as a promising material for photo thermal therapy applications in future. |
| Databáze: | OpenAIRE |
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