Amyloidosis associated bleeding diatheses in the surgical patient
| Autor: | Alan R. Mizutani, C. F. Ward |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Abnormal platelet aggregation medicine.medical_treatment Blood Loss Surgical Tissue Adhesions Hemorrhagic Disorders Peritoneal Diseases Laparotomy Intestine Small medicine Coagulopathy Coagulation testing Humans Mesentery Hematoma business.industry Amyloidosis General Medicine Middle Aged medicine.disease Surgery Bleeding diathesis Bowel obstruction Anesthesiology and Pain Medicine Female Fresh frozen plasma business Intestinal Obstruction |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 37(8) |
| ISSN: | 0832-610X |
| Popis: | The coagulopathies associated with amyloidosis have not been widely appreciated. We encountered a patient with amyloidosis and mildly abnormal coagulation studies who presented for an emergency laparotomy for acute bowel obstruction. Upon gentle manipulation of the bowel, an unexpected bleeding diathesis was manifested by the formation of several large haematomas resulting in a large amount of blood loss (approximately 800 ml). Numerous defects of platelet function and coagulation have been associated with amyloidosis, including abnormal platelet aggregation, increased vascular fragility, factor IX and X deficiencies, decreased levels of alpha-2-plasmin inhibitor, and increased levels of plasminogen. Intraoperative therapy for our patient included the rapid administration of four units of fresh frozen plasma and ten units of platelet concentrate. A review of the pathology and therapeutic modalities for this potentially life-threatening complication is presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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