Bacterial growth physiology and RNA metabolism
| Autor: | Matthieu Jules, Etienne Dervyn, Anne-Gaëlle Planson, Vincent Sauveplane |
|---|---|
| Přispěvatelé: | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Rok vydání: | 2019 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Biophysics Metabolic network Computational biology Guanosine Tetraphosphate Biochemistry 03 medical and health sciences Global regulation Structural Biology Gene expression Genetics Molecular Biology Gene 030304 developmental biology RNA metabolism (p)ppGpp 2. Zero hunger Flexibility (engineering) Regulation of gene expression 0303 health sciences biology Bacteria 030306 microbiology RNA Prokaryote Gene Expression Regulation Bacterial biology.organism_classification Adaptation Physiological RNA Bacterial GTP Bacteria Growthrate |
| Zdroj: | Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Elsevier, 2020, 1863 (5), pp.194502. ⟨10.1016/j.bbagrm.2020.194502⟩ |
| ISSN: | 1876-4320 1874-9399 |
| Popis: | International audience; Bacteria are sophisticated systems with high capacity and flexibility to adaptto various environmental conditions. Each prokaryote how ever possesses a defined metabolic network, which set sits over all metabolic capacity, and there fore the maximal growth rate that can be reached. To achieve optimal growth, bacteria adopt various molecular strategies to optimally adjust gene expression and optimize resource allocation according to the nutrient availability. There sulting physiological changes are often accompanied by changes in the growth rate, and by global regulation of gene expression. The growth-rate-dependent variation of the abundances in the cellular machineries, together with condition-specific regulatory mechanisms, affect RNA metabolism and fate and pose a challenge forrational gene expression reengineering of synthetic circuits. This article is part of a Special Issue entitled: RNA and gene control in bacteria, edited by Dr. M. Guillierand F. Repoila. |
| Databáze: | OpenAIRE |
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