Nanomedicine in the treatment of diabetic nephropathy
| Autor: | Havish Shukla, Rakesh K. Tekade, HariPriya Koppisetti, Shreya Pande, Aayushi S. Ditani, Pragyan Paramita Mallick, Kiran Kalia, Umesh Kathar, Nimeet Desai, Bhagwat Sirsat |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology medicine.medical_specialty business.industry Incidence (epidemiology) 030232 urology & nephrology Disease medicine.disease Diabetic nephropathy 03 medical and health sciences Drug Delivery Systems Nanomedicine 030104 developmental biology 0302 clinical medicine Targeted drug delivery Internal medicine Diabetes mellitus Drug Discovery Pandemic medicine Humans Hypoglycemic Agents Molecular Medicine Diabetic Nephropathies business |
| Zdroj: | Future Medicinal Chemistry. 13:663-686 |
| ISSN: | 1756-8927 1756-8919 |
| Popis: | Globally, diabetic nephropathy (DN) is the foremost cause of end-stage renal disease. With the incidence of diabetes increasing day by day, DN's occurrence is expected to surge to pandemic proportions. Current available therapeutic interventions associated with DN emphasize blood pressure, glycemia and lipid control while ignoring DN's progression mechanism at a molecular level. This review sheds light on the molecular insights involved in DN to help understand the initiation and progression pattern. Further, we summarize novel strategies with reported applications in developing a nanomedicine-based platform for DN-targeted drug delivery to improve drug efficacy and safety. |
| Databáze: | OpenAIRE |
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