Modeling Neurodegenerative Disorders in Drosophila melanogaster

Autor:	Harris Bolus, Grace Boekhoff-Falk, Kassi L. Crocker, Stanislava Chtarbanova
Rok vydání:	2020
Předmět:	Traumatic brain injury Catalysis lcsh:Chemistry Inorganic Chemistry Genetic model medicine Physical and Theoretical Chemistry Drosophila (subgenus) Amyotrophic lateral sclerosis lcsh:QH301-705.5 Molecular Biology neuroregeneration Spectroscopy biology Organic Chemistry Neurodegeneration neurodegeneration General Medicine biology.organism_classification medicine.disease Neuroregeneration Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 Ataxia-telangiectasia Drosophila Drosophila melanogaster Neuroscience
Zdroj:	International Journal of Molecular Sciences, Vol 21, Iss 3055, p 3055 (2020)
ISSN:	1422-0067
Popis:	Drosophila melanogaster provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in Drosophila modeling Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using Drosophila models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960de3f85e6fbdd5525275f28624f9b7 https://doi.org/10.3390/ijms21093055 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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