Effects of prostaglandin inhibition on the bone activities associated with the spontaneous drift of molar teeth in the rat
| Autor: | J. J. Lasfargues, J. L. Saffar |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Molar medicine.medical_specialty Prostaglandin Antagonists Indomethacin Osteoclasts Prostaglandin Biology Mandibular first molar Bone remodeling chemistry.chemical_compound Tooth Drift Osteoclast Internal medicine Alveolar Process medicine Animals Bone Resorption Rats Wistar Tooth Migration Anatomy Agricultural and Biological Sciences (miscellaneous) Rats Resorption Demineralization medicine.anatomical_structure Endocrinology chemistry Bone Remodeling |
| Zdroj: | The Anatomical Record. 234:310-316 |
| ISSN: | 1097-0185 0003-276X |
| DOI: | 10.1002/ar.1092340303 |
| Popis: | Little is known about local bone regulation that enables spontaneous molar tooth drift. In this study the role of prostaglandins (PGs) were investigated in the rat by inhibiting PG-synthesis with indomethacin (7 mg/kg/d). Untreated animals were killed at the start of the experiment, while treated ones were killed after 3, 7, or 14 days of treatment. Mandibles were processed for histomorphometry without demineralization. Changes in osteoclasts and extent of the different steps of the bone remodeling sequence (resorption, reversal, and formation) were assessed along the remodeling side of the socket of the buccal root of the first molar. The total number of osteoclasts decreased after 7 days of PG inhibition (P |
| Databáze: | OpenAIRE |
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