Therapeutic Potentials of A2B Adenosine Receptor Ligands: Current Status and Perspectives
| Autor: | A. M. Y. Jaber, Sara Samarneh, Nikhil Agrawal, Balakumar Chandrasekaran, Ghadir Kassab |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
Adenosine A2 Receptor Agonists media_common.quotation_subject Inflammation Disease Ligands Receptor Adenosine A2B Bioinformatics 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Humans Receptor 030304 developmental biology G protein-coupled receptor media_common Pharmacology 0303 health sciences business.industry Cancer medicine.disease Adenosine receptor Adenosine A2 Receptor Antagonists 030220 oncology & carcinogenesis medicine.symptom Signal transduction business Signal Transduction |
| Zdroj: | Current Pharmaceutical Design. 25:2741-2771 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612825666190717105834 |
| Popis: | Background: Adenosine receptors (ARs) are classified as A1, A2A, A2B, and A3 subtypes belong to the superfamily of G-protein coupled receptors (GPCRs). More than 40% of modern medicines act through either activation or inhibition of signaling processes associated with GPCRs. In particular, A2B AR signaling pathways are implicated in asthma, inflammation, cancer, ischemic hyperfusion, diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, and kidney disease. Methods: This article reviews different disease segments wherein A2B AR is implicated and discusses the potential role of subtype-selective A2B AR ligands in the management of such diseases or disorders. All the relevant publications on this topic are reviewed and presented scientifically. Results: This review provides an up-to-date highlight of the recent advances in the development of novel and selective A2B AR ligands and their therapeutic role in treating various disease conditions. A special focus has been given to the therapeutic potentials of selective A2B AR ligands in the management of airway inflammatory conditions and cancer. Conclusions: This systematic review demonstrates the current status and perspectives of A2B AR ligands as therapeutically useful agents that would assist medicinal chemists and pharmacologists in discovering novel and subtype-selective A2B AR ligands as potential drug candidates. |
| Databáze: | OpenAIRE |
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