Endothelin and sarafotoxin: Influence on steroid-regulated motility of rat uterus
| Autor: | Zvi Wollberg, Avner Bdolah, Nili Shinnar, Elazar Kochva |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.hormone
medicine.medical_specialty Contraction (grammar) Ovariectomy Uterus Motility Viper Venoms Biology General Biochemistry Genetics and Molecular Biology Uterine contraction Endothelins Uterine Contraction Internal medicine medicine Animals Vasoconstrictor Agents General Pharmacology Toxicology and Pharmaceutics Estradiol Myometrium Rats Inbred Strains General Medicine Rats Endocrinology medicine.anatomical_structure Ovariectomized rat Female medicine.symptom Endothelin receptor |
| Zdroj: | Life Sciences. 51:PL57-PL60 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(92)90032-k |
| Popis: | The sarafotoxins (SRTX) and endothelins (ET) were shown to influence the motility of the isolated rat uterus by inducing an increase in the rate and in the maximum tension of the spontaneous rhythmic contractions and a suppression of the relaxation phase of these contractions. Ovariectomized rats, 24 weeks post-operation, show no spontaneous motility of their uteri and the SRTX/ET peptides induce only a slight tonic increase in the uterine tension. Treatment with 17 beta estradiol restores spontaneous motility and sensitivity to the SRTX/ET peptides in all three contraction modes. It is concluded that the influence of the SRTXs and ETs on uterine motility depends on the hormonal status of the animal. |
| Databáze: | OpenAIRE |
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