Down-regulation of PERK enhances resistance to ionizing radiation
| Autor: | Deepu Oommen, Kevin M. Prise |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
PERK
Ionizing radiation endocrine system DNA Repair Cell Survival DNA repair Biophysics Down-Regulation Apoptosis Biology Biochemistry SIGNALING PATHWAYS eIF-2 Kinase ENDOPLASMIC-RETICULUM STRESS Downregulation and upregulation MAMMALIAN-CELLS Cell Line Tumor Radiation Ionizing KINASE BREAST-CANCER Humans Gene Silencing Phosphorylation PHOSPHORYLATION Protein kinase A Molecular Biology INDUCED APOPTOSIS UNFOLDED PROTEIN RESPONSE Kinase Endoplasmic reticulum Cell Biology Cell biology DNA-DAMAGE Cancer cell Unfolded protein response DNA damage ER-stress TRANSLATION Signal transduction Transcription Factor CHOP DNA Damage |
| Zdroj: | Oommen, D & Prise, K M 2013, ' Down-regulation of PERK enhances resistance to ionizing radiation ', Biochemical and Biophysical Research Communications, vol. 441, no. 1, pp. 31-35 . https://doi.org/10.1016/j.bbrc.2013.09.129 |
| ISSN: | 0006-291X |
| Popis: | Although, ionizing radiation (IR) has been implicated to cause stress in endoplasmic reticulum (ER), how ER stress signaling and major ER stress sensors modulate cellular response to IR is unclear. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER transmembrane protein which initiates unfolded protein response (UPR) or ER stress signaling when ER homeostasis is disturbed. Here, we report that down-regulation of PERK resulted in increased clonogenic survival, enhanced DNA repair and reduced apoptosis in irradiated cancer cells. Our study demonstrated that PERK has a role in sensitizing cancer cells to IR. |
| Databáze: | OpenAIRE |
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