International expert group collaboration for developing an adverse outcome pathway for radiation induced leukemia
| Autor: | Dmitry Klokov, Kimberly Applegate, Christophe Badie, Dag Anders Brede, Fieke Dekkers, Melis Karabulutoglu, Yevgeniya Le, Eric Andreas Rutten, Katalin Lumniczky, Maria Gomolka |
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| Přispěvatelé: | Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), University of Kentucky College of Medicine, Public Health England [London], Centre for Environmental Radioactivity (CERAD), Canadian Nuclear Laboratories, Centre for Radiation, Chemical and Environmental Hazards, National Research Institute for Radiobiology & Radiohygiene, Bundesamt für Strahlenschutz - Federal Office for Radiation Protection (BfS), the Research Council of Norway(RCN) under the Center of Excellence (CoE) funding scheme [ProjectNo. 223268], IRSN, European Project: 900009,RadoNorm |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Leukemia
Radiation-Induced radiationinduced leukemia Leukemia Adverse Outcome Pathways Radiological and Ultrasound Technology [SDV]Life Sciences [q-bio] key event risk assessment low-dose radiation acute myeloid leukemia adverse outcome pathway radiation-induced leukaemia AML leukaemia Humans Radiology Nuclear Medicine and imaging acute myeloid leukaemia molecular initiating event ionizing radiation radiation protection |
| Zdroj: | International Journal of Radiation Biology International Journal of Radiation Biology, 2023, 98 (12), pp.1802-1815. ⟨10.1080/09553002.2022.2117873⟩ |
| ISSN: | 0955-3002 1362-3095 |
| Popis: | International audience; Purpose: The concept of the adverse outcome pathway (AOP) has recently gained significant attention as to its potential for incorporation of mechanistic biological information into the assessment of adverse health outcomes following ionizing radiation (IR) exposure. This work is an account of the activities of an international expert group formed specifically to develop an AOP for IR-induced leukemia. Group discussions were held during dedicated sessions at the international AOP workshop jointly organized by the MELODI (Multidisciplinary European Low Dose Initiative) and the ALLIANCE (European Radioecology Alliance) associations to consolidate knowledge into a number of biological key events causally linked by key event relationships and connecting a molecular initiating event with the adverse outcome. Further knowledge review to generate a weight of evidence support for the Key Event Relationships (KERs) was undertaken using a systematic review approach. Conclusions: An AOP for IR-induced acute myeloid leukemia was proposed and submitted for review to the OECD-curated AOP-wiki (aopwiki.org). The systematic review identified over 500 studies that link IR, as a stressor, to leukemia, as an adverse outcome. Knowledge gap identification, although requiring a substantial effort via systematic review of literature, appears to be one of the major added values of the AOP concept. Further work, both within this leukemia AOP working group and other similar working groups, is warranted and is anticipated to produce highly demanded products for the radiation protection research community. |
| Databáze: | OpenAIRE |
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