Alveolar capillary dysplasia with left heart obstruction - rare but lethal
| Autor: | E P Schneider, V C Stark, H Schäfer, Urda Gottschalk, P A Hauck, R Kozlik-Feldmann, D Biermann |
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| Rok vydání: | 2018 |
| Předmět: |
Alveolar capillary dysplasia
medicine.medical_specialty Lung biopsy Disease 030204 cardiovascular system & hematology Persistent Fetal Circulation Syndrome Ventricular Outflow Obstruction 03 medical and health sciences 0302 clinical medicine Fatal Outcome Pathognomonic Internal medicine medicine Humans Hypoxia business.industry Persistent pulmonary hypertension Infant Newborn medicine.disease Pulmonary Alveoli Dyspnea 030228 respiratory system Respiratory failure Pediatrics Perinatology and Child Health Cardiology Hypoplastic aortic arch Neonatal lung business Acidosis Tomography X-Ray Computed |
| Zdroj: | Journal of neonatal-perinatal medicine. 11(3) |
| ISSN: | 1878-4429 |
| Popis: | Alveolar capillary dysplasia (ACD) is a rare neonatal lung disease characterized anatomically by a defective and hypoplastic development of pulmonary alveoli leading to persistent pulmonary hypertension (PPHN) and finally lethal respiratory failure. It is often associated with congenital left heart obstruction. Given the fatal prognosis an early diagnosis is important. However, due to the fast onset of PPHN in neonates and lack of pathognomonic signs for its cause, safe and fast detection of ACD is challenging. Therefore, following the exclusion of cardiac and common pulmonary causes, lung biopsy becomes essential for diagnosis.We hereby report a case of ACD with atrial septal defect type one and hypoplastic aortic arch with an ante-mortem diagnosis and discuss the current state of medicine in relation to ACD. |
| Databáze: | OpenAIRE |
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