A CASE-CONTROL STUDY OF SMOKING AND ALZHEIMER'S DISEASE

Autor:	V, Hillier, E, Salib
Rok vydání:	1997
Předmět:	Aged 80 and over Male Risk Smoking Middle Aged Psychiatry and Mental health England Alzheimer Disease Risk Factors Case-Control Studies Odds Ratio Humans Female Geriatrics and Gerontology Geriatric Assessment Aged
Zdroj:	International Journal of Geriatric Psychiatry. 12:295-300
ISSN:	1099-1166 0885-6230
DOI:	10.1002/(sici)1099-1166(199703)12:3<295::aid-gps476>3.0.co;2-3
Popis:	To study the association between Alzheimer's disease and smoking history.An unmatched case-control study.Psychogeriatric unit serving an elderly population of Warrington.2 years 1991-1993.198 cases of Alzheimer's disease (ADRDA-NINCDS diagnostic criteria) were compared to two selected control groups (164 other dementias and 176 non-dementing group) with respect to their smoking history.Relative risk (odds ratio) of Alzheimer's disease.The odds ratio for Alzheimer's disease in patients who smoked was 0.68 (95% CI 0.47-0.98). The negative association was statistically significant only in male patients, OR 0.45 95% CI (0.23-0.87), p0.05. The inverse association was also only significant in patients with family history of dementia, OR 0.34 95% CI (0.12-0.92), p0.05.The study supports previous findings of an inverse relationship between smoking and Alzheimer's disease. This, however, does not suggest that smoking is used as a preventive measure for Alzheimer's disease.
Databáze:	OpenAIRE
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