Effect of Aerodiol administration on ocular arteries in postmenopausal women
| Autor: | Bumin Degirmenci, Dagistan Tolga Arioz, Figen Kir Sahin, Ramazan Albayrak, Emine Coşar, Murat Acar, Gülengül Köken |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Central retinal artery
medicine.medical_specialty genetic structures Retinal Artery Endocrinology Diabetes and Metabolism Diastole Hemodynamics Blood Pressure Placebo Body Mass Index Placebos Ophthalmic Artery Endocrinology Double-Blind Method medicine.artery Internal medicine medicine Humans Administration Intranasal Cross-Over Studies Estradiol business.industry Obstetrics and Gynecology Blood flow Middle Aged Crossover study Surgery Postmenopause Ophthalmic artery Cardiology Female Nasal administration business |
| Zdroj: | Gynecological Endocrinology. 24:173-177 |
| ISSN: | 1473-0766 0951-3590 |
| DOI: | 10.1080/09513590701807431 |
| Popis: | The aim of the present study was to evaluate the alteration of ocular blood hemodynamics after intranasal administration of 17beta-estradiol, through measurement of the ophthalmic artery (OA) and the central retinal artery (CRA) using color duplex sonography.Thirty healthy women who had been naturally postmenopausal for at least 1 year were enrolled in the study. A randomized, placebo-controlled, crossover, double-blinded study was conducted of the acute effect of 17beta-estradiol (Aerodiol; Servier, Chambrayles-Tours, France) on OA and CRA blood flow using color duplex sonography.The peak systolic and end diastolic velocities of the CRA were increased significantly after 17beta-estradiol administration compared with placebo. A significant decrease was also found in the pulsatility and resistive indices of the CRA. However, there were no statistically significant differences in OA flow velocities or pulsatility and resistive indices.Nasal 17beta-estradiol administration in postmenopausal women causes an improvement in the ocular vascular Doppler indices. These results suggest that there could be a positive effect of Aerodiol on middle-sized arteries and arterioles. |
| Databáze: | OpenAIRE |
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