Dose response of dexmedetomidine-induced resistance to hypoxia in mice
| Autor: | Jingfu Chen, Yueting Wang, Liqiu Mo, Xiaoxiao Hua, Rui-Xian Guo, Wanying Pan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Bradycardia Cancer Research medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Propranolol Biology Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate Adrenergic alpha-2 Receptor Agonists Genetics medicine Animals Hypnotics and Sedatives Dexmedetomidine Hypoxia Molecular Biology Saline Heart Hypoxia (medical) Hypothermia 030104 developmental biology Endocrinology Oncology Immunology Molecular Medicine medicine.symptom 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Molecular Medicine Reports. 14:3237-3242 |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Tolerance to hypoxia can be induced by reducing oxygen consumption. Dexmedetomidine (DEX) decreases locomotor activity and induces bradycardia and hypothermia in mice. The present study examined the hypothesis that DEX improves hypoxia tolerance in mice. Adult mice received an intraperitoneal injection of 1, 5, 10, 20, 40, 80, 160 or 320 µg/kg DEX, 20 mg/kg propranolol or saline. Acute hypoxic conditions were induced by placing the mice in a limited enclosed container with soda lime. Core body temperature (CBT) and heart rate (HR) were measured prior to and 30 min after drug administration. Survival time was monitored in the sealed container. Survival times (mean ± standard deviation) of mice in the saline, 1, 5, 10, 20, 40, 80, 160 and 320 µg/kg DEX, and the 20 mg/kg propranolol groups were 22.4±1.1, 23.4±1.1, 26.0±0.9, 36.9±5.2, 42.4±2.9, 43.2±2.3, 58.2±4.2, 80.5±4.0, 79.2±6.0, and 38.2±2.8 min, respectively. Pretreatment with propranolol and 10, 20, 40, 80, 160 or 320 µg/kg DEX, but not 1 or 5 µg/kg, significantly prolonged survival time compared with saline‑injected mice (P |
| Databáze: | OpenAIRE |
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