Sensitivity of Action Potential Triggering is Normally Distributed as a Function of Mean Fractional Receptor Activation
| Autor: | M. P. J. Paloheimo, O. A. P. Santanen |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Agonist
medicine.drug_class Muscle Fibers Skeletal Cell Population Neuromuscular transmission Action Potentials Critical Care and Intensive Care Medicine Models Biological 03 medical and health sciences 0302 clinical medicine Reference Values medicine Humans 030212 general & internal medicine Receptor education Evoked Potentials Ulnar Nerve education.field_of_study Electromyography business.industry Antagonist 030208 emergency & critical care medicine Function (mathematics) Sigmoid function Isoquinolines Electric Stimulation Receptors Neurotransmitter Mivacurium Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Biophysics business Neuromuscular Nondepolarizing Agents |
| Zdroj: | Anaesthesia and Intensive Care. 29:371-376 |
| ISSN: | 1448-0271 0310-057X |
| DOI: | 10.1177/0310057x0102900407 |
| Popis: | In 1968, Waud presented his general pharmacodynamic model consisting of two sub-functions that divide the pharmacodynamic cascade from drug concentration to cell effect/response into two successive steps: Step one (the internal function) characterizes the binding of agonist drug molecules to the post-synaptic receptors and the subsequent receptor activation, and step two (the external/effect function) characterizes the cell response induced by a critical receptor pool activation. According to Waud, the problem of determining the relation between drug concentration and cell response/effect reduces to the second step in the pharmacodynamic cascade. In this paper, we suggest a new external/effect-function, the cumulative Normal population-effect-function. It describes how muscle fibre excitability (all-or-none phenomenon) is distributed as a function of mean fractional receptor activation in a muscle fibre population. This function fits to empirical data and explains logically why the sigmoid muscle effect, from minimal to maximal, is seen in such a narrow range of antagonist concentrations and receptor occupancies. |
| Databáze: | OpenAIRE |
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