The influence of Parkinson's disease on the functional connectivity of the motor loop of human basal ganglia
| Autor: | Fernando Monton, Ingrid Morales, Clara Rodriguez-Sabate, Manuel Rodriguez |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Parkinson's disease Thalamus Substantia nigra Biology Basal Ganglia 03 medical and health sciences 0302 clinical medicine Neural Pathways Basal ganglia medicine Humans Aged Resting state fMRI Putamen Parkinson Disease Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases 030104 developmental biology medicine.anatomical_structure nervous system Neurology Female Neurology (clinical) Geriatrics and Gerontology Primary motor cortex Neuroscience Nucleus 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonism & Related Disorders. 63:100-105 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2019.02.031 |
| Popis: | Current basal ganglia models integrate information obtained from humans and animals to explain motor disorders in Parkinson's disease. These models explain some motor disturbances of Parkinson's disease (PD), but different clinical observations which remain unexplained have promoted the development of new basal ganglia (BG) models. The present study uses the time-relationship (partial correlation) of the BOLD-signal fluctuations to study the influence of PD on BG interactions of 17 age-matched controls (58.7 ± 5.3 years of age) and 24 PD patients (56.7 ± 8.4 years of age). Controls showed a complex functional connectivity of BG with a positive correlation between some nuclei (synchrony) and a negative correlation between other nuclei (anti-synchrony). This functional connectivity was different in PD-patients who showed: 1. an increased synchrony between the primary motor cortex(M1)-external pallidum(GPe), putamen(Put)-GPe, Put-subthalamic nucleus (STN), STN-internal pallidum (GPi), STN-motor thalamus (Tal), STN-GPi substantia nigra (SN) and SN-Tal, 2. a decreased synchrony between Put-GPi, GPe-STN, GPe-SN, STN-SN and GPi-SN, and 3. an increased anti-synchrony between GPe-SN and GPi-Tal. In control subjects, the motor-task increased the Put-Tal, GPi-SN and STN-Tal synchrony, decreased the STN-GPi and STN-SN synchrony and decreased the M1-GPe and the GPe-GPi anti-synchrony. The effect of the motor-task was very different in PD-patients, in whom it induced a decrease of the M1-GPe, STN-GPi and SN-Tal synchrony and a decrease of the GPe-Tal and GPe-SN anti-synchrony. Functional connectivity imaging methods may provide data that cannot be obtained by other methods in humans, and that may help to understand the physiology of BG and its deterioration in PD. |
| Databáze: | OpenAIRE |
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