Red cell distribution width as a marker of activity in inflammatory bowel disease: a narrative review
| Autor: | Marios Katsaros, Olga Giouleme, Paschalis Paschos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Crohn’s disease
Crohn's disease medicine.diagnostic_test business.industry Anemia Red cell distribution width Gastroenterology Complete blood count Red blood cell distribution width Disease Review Article medicine.disease Ulcerative colitis Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease 030220 oncology & carcinogenesis Immunology medicine Anisocytosis 030211 gastroenterology & hepatology business disease activity ulcerative colitis |
| Zdroj: | Annals of Gastroenterology |
| ISSN: | 1792-7463 1108-7471 |
| Popis: | Red blood cell distribution width is a parameter measured automatically in every complete blood count that actually reflects the degree of anisocytosis of the red blood cell population. It is a cost-effective tool used in everyday clinical practice along with other parameters to define and narrow the cause of anemia. In a series of pathologic entities, such as cardiovascular diseases, autoimmune diseases, malignancy, chronic renal diseases and chronic respiratory diseases, where inflammation and oxidative stress comprise the major pathophysiologic insults, red cell distribution width behaves as a significant and competent marker able to predict and assess disease activity and severity. A number of clinical studies based on these observations have aimed to evaluate its potential utility as an index of activity in inflammatory bowel disease. In this narrative review we present data from the international literature regarding its ability to express disease activity and we look into its relation with clinical, laboratory and endoscopic indices used to identify active disease. According to the results of published clinical trials, red cell distribution width is considerably correlated with disease activity and might serve as an index to differentiate Crohn's disease from ulcerative colitis. |
| Databáze: | OpenAIRE |
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