Influence of Granulocyte-Macrophage Colony-Stimulating Factor or Influenza Vaccination on HLA-DR, Infection and Delirium Days in Immunosuppressed Surgical Patients: Double Blind, Randomised Controlled Trial
| Autor: | Alexander Schiemann, Marco Paupers, Gunnar Lachmann, Alawi Luetz, Marcus Bahra, Klaus-Dieter Wernecke, Claudia Spies, Clarissa von Haefen, M. Renius, Christian Meisel |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment lcsh:Medicine 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit Placebo Monocytes law.invention Immunocompromised Host Immune system Esophagus Randomized controlled trial Double-Blind Method law Internal medicine Influenza Human medicine Humans lcsh:Science Pancreas Aged Multidisciplinary business.industry lcsh:R Vaccination Delirium Granulocyte-Macrophage Colony-Stimulating Factor Immunosuppression HLA-DR Antigens Middle Aged Surgery medicine.anatomical_structure Granulocyte macrophage colony-stimulating factor Influenza Vaccines lcsh:Q Female medicine.symptom business medicine.drug Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 12, p e0144003 (2015) |
| ISSN: | 1932-6203 |
| Popis: | Purpose Surgical patients are at high risk for developing infectious complications and postoperative delirium. Prolonged infections and delirium result in worse outcome. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and influenza vaccination are known to increase HLA-DR on monocytes and improve immune reactivity. This study aimed to investigate whether GM-CSF or vaccination reverses monocyte deactivation. Secondary aims were whether it decreases infection and delirium days after esophageal or pancreatic resection over time. Methods In this prospective, randomized, placebo-controlled, double-blind, double dummy trial setting on an interdisciplinary ICU of a university hospital 61 patients with immunosuppression (monocytic HLA-DR [mHLA-DR] |
| Databáze: | OpenAIRE |
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