Injectable and fast self-healing protein hydrogels
| Autor: | Shangtong Jiang, Xiaodong Yang, Fei Li, Junqiu Liu, Xiaotong Fan, Tengfei Yan, Jiayun Xu, Bo Ren, Xin Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biocompatibility
Reducing agent Cell Survival Injectable hydrogels Biocompatible Materials macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences law.invention Injections Tissue engineering law Tensile Strength Animals Humans 3D bioprinting Protein molecules Chemistry technology industry and agriculture Hydrogels Serum Albumin Bovine General Chemistry Hydrogen Peroxide 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Self-healing Self-healing hydrogels MCF-7 Cells Cattle 0210 nano-technology Rheology Oxidation-Reduction Biomedical engineering |
| Zdroj: | Soft matter. 15(38) |
| ISSN: | 1744-6848 |
| Popis: | Injectable hydrogels are adapted to irregularities in the desired location by injection as a liquid and gelation in situ. However, traditional slow-gelling injectable hydrogels may result in loss of cargo (cells/drugs) as well as diffusion at the target site, and extremely rapid gelation may lead to undesired premature coagulation. These practical problems can be solved by using self-healing hydrogels. Herein, through the reduction of disulfide bonds in BSA protein by using a reducing agent, the disulfide bonds between the individual BSA protein molecules are re-matched to form a network structure, thereby forming a protein hydrogel. This hydrogel shows an efficient and rapid self-healing property, and the broken protein hydrogel can be fast repaired within 1–2 minutes in response to H2O2 stimulation, and the repair efficiency reached up to 100%. The hydrogel can be extruded using only a pinhole syringe, and cytotoxicity experiments have demonstrated excellent biocompatibility of the protein hydrogel. This non-toxic, injectable, fast self-healing protein hydrogel is expected to be widely used in biomedical, tissue engineering, injectable gel, 3D bioprinting, and other applications. |
| Databáze: | OpenAIRE |
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