Effects of prostaglandin F2α (PGF2α) on secretion of pregnancy specific protein B (PSPB) and placentome weights in intact or ovariectomized 90 to 100 day pregnant ewes
| Autor: | K.S. Ledgerwood, K.D. Nusser, Yoshie S. Weems, R.G. Sasser, K. Miller-Patrick, Y. Tanaka, C.W. Weems, D.L. Vincent |
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| Rok vydání: | 1994 |
| Předmět: |
Specific protein
medicine.medical_specialty Time Factors Ovariectomy Placenta Prostaglandin Pregnancy Proteins Dinoprost Body weight Biochemistry Andrology chemistry.chemical_compound Endocrinology Pregnancy Internal medicine medicine Animals Secretion Sheep business.industry Uterus Venous Plasma medicine.disease Treatment period chemistry Ovariectomized rat Female business |
| Zdroj: | Prostaglandins. 48:377-387 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(94)90004-3 |
| Popis: | Vehicle or 8 or 16 mg PGF2 alpha/58 kg/body weight (BW) was given intramuscularly to intact or ovariectomized 90 to 100 day pregnant ewes in two separate experiments. Treatment with 8 mg PGF2 alpha in intact 90 to 100 day pregnant ewes increased (Por = 0.05) placentome weights, but not in ovariectomized 90 to 100 day pregnant ewes (Por = 0.05). Concentrations of PSPB in uterine venous plasma of control 90 to 100 day intact pregnant ewes over the 72 hour sampling period averaged 52 +/- 5 ng/ml. Profiles of PSPB in uterine plasma in the 16 mg PGF2 alpha/58 kg/BW-treated ewes differed (Por = 0.05) from control or 8 mg PGF2 alpha-treated 90 to 100 day intact pregnant ewes. Pregnancy specific protein B was increased (Por = 0.05) at 64 hr in intact 90 to 100 day pregnant ewes by treatment with 8 mg PGF2 alpha/58 kg/BW. There was a quadratic increase (Por = 0.09) in PSPB in uterine venous plasma of all three treatment groups of intact 90 to 100 day pregnant ewes. Concentrations of PSPB in uterine venous plasma of control 90 to 100 day ovariectomized pregnant ewes over the 72 hr treatment period averaged 90 +/- 5 ng/ml. Profiles of PSPB did not differ among the vehicle, 8 mg PGF2 alpha or 16 mg PGF2 alpha-treated ovariectomized 90 to 100 day pregnant ewes. There was a quadratic increase (Por = 0.10) in PSPB in uterine venous plasma of ovariectomized 90 to 100 day pregnant ewes treated with 8 or 16 mg PGF2 alpha/58 kg/BW. It is suggested that PSPB may have a role in regulating placental steroidogenesis. |
| Databáze: | OpenAIRE |
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