Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection
| Autor: | Matthias J. Reddehase, Natascha K. A. Grzimek, Christof K. Seckert, Angélique Renzaho |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Microbiology (medical) Stromal cell medicine.medical_treatment Immunology Congenital cytomegalovirus infection Cytomegalovirus Hematopoietic stem cell transplantation medicine.disease_cause Herpesviridae Immunocompromised Host Mice Betaherpesvirinae medicine Animals Immunology and Allergy Mice Inbred BALB C biology Hematopoietic Stem Cell Transplantation virus diseases General Medicine biology.organism_classification medicine.disease Virology Tissue Donors Virus Latency Transplantation surgical procedures operative medicine.anatomical_structure Cytomegalovirus Infections Female Bone marrow Stem cell |
| Zdroj: | Medical Microbiology and Immunology. 197:251-259 |
| ISSN: | 1432-1831 0300-8584 |
| DOI: | 10.1007/s00430-008-0094-1 |
| Popis: | Hematopoietic stem cell transplantation (HSCT) bears a risk of reactivating latent cytomegalovirus (CMV) in either the transplanted hematopoietic donor cells or in parenchymal and stromal tissue cells of the immunocompromised recipient, or in both. While reactivated human CMV in recipients of organ transplantations is frequently the virus variant of the donor, this is not usually the case in HSCT recipients. Here we have used experimental sex-mismatched HSCT in the BALB/c mouse model to test if latent murine CMV from CMV-immune donors is transmitted with bone marrow cells to naive immunocompromised recipients. |
| Databáze: | OpenAIRE |
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