A quantitative investigation of some actions of a haloalkylamine analogue of thymoxamine on smooth muscle
| Autor: | A.T. Birmingham, K. Ernest |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
medicine.medical_specialty Guinea Pigs Agonist drugs Ileum Norepinephrine Vas Deferens Smooth muscle Internal medicine Ethylamines medicine Animals Aorta Pharmacology Chemistry Haloalkylamine Chloramines Muscle Smooth Rats Blockade medicine.anatomical_structure Endocrinology Rat Stomach Antagonism Drug Antagonism Quantitative analysis (chemistry) Muscle Contraction |
| Zdroj: | European Journal of Pharmacology. 4:298-302 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(68)90097-6 |
| Popis: | A quantitative analysis was made of the antagonism by compound WV 0062, N -(2-chloroethyl)- N -[2-(4-chloro-2-isopropyl-5- methylphenoxy)-1-methylethyl] ethylamine hydrochloride, of the responses of some isolated smooth muscle preparations to agonist drugs. The antagonism of noradrenaline or acetylcholine-induced contractions of smooth muscle had the characteristics of non-competitive blockade; the blockade was insurmountable and seemed to be very long-lasting. WV 0062 contracted the guinea-pig ileum and the rat stomach strip. It is concluded that WV 0062 is a very potent compound (pA h approximately 10) which exhibits the non-competitive blocking action and the non-specificity associated with other haloalkylamines and is therefore unlike its analogue, thymoxamine, which is a relatively specific competitive blocking agent at a -receptors. |
| Databáze: | OpenAIRE |
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