Multicompartmentalized vesosomes containing DOX loaded liposomes and 5FU loaded liposomes for synergistic tumor treatment
| Autor: | Wei Zong, Tianmeng Sun, Mingdong Dong, Wenlong Cheng, Xunan Zhang, Jialiang Wang, Xiaojun Han |
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| Rok vydání: | 2019 |
| Předmět: |
Drug
DRUG-RELEASE Combination therapy media_common.quotation_subject PH-SENSITIVE LIPOSOMES 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Catalysis VESICLES HeLa DELIVERY In vivo Materials Chemistry medicine Doxorubicin COMBINATION media_common Liposome biology Chemistry Tumor therapy General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Tumor growth inhibition 0210 nano-technology medicine.drug |
| Zdroj: | Zhang, X, Zong, W, Wang, J, Dong, M, Cheng, W, Sun, T & Han, X 2019, ' Multicompartmentalized vesosomes containing DOX loaded liposomes and 5FU loaded liposomes for synergistic tumor treatment ', New Journal of Chemistry, vol. 43, no. 12, pp. 4895-4899 . https://doi.org/10.1039/c9nj00238c |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c9nj00238c |
| Popis: | The first priority of drug combination therapy in the treatment of cancer is to achieve enhanced therapeutic efficacy and reduced side effects. The main issue in drug combination therapy is the inscrutable interaction between different drug components. Herein, we developed a multicompartmentalized architecture as a new delivery system. A host liposome encapsulates multiple guest liposomes, where various drug components were loaded into disparate compartments separately. This strategy avoids the interaction among different components before their arrival at the targeting sites and provides the fixed drug combination ratio as needed. Doxorubicin (DOX) and 5-fluorouacil (5FU) loaded smaller liposomes were encapsulated into bigger liposomes with a fixed dose ratio of DOX to 5FU. In vivo tumor growth inhibition by vesosomes was evaluated in HeLa tumor-bearing nude mice, which confirms the enhancement of the delivery system on the synergism of the drug combination. |
| Databáze: | OpenAIRE |
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