Association of maternal nutrition with transient neonatal hyperinsulinism
| Autor: | Jean Claude Carel, Yanis Montcho, Mathilde Louvigne, Isabelle Souto, Géraldine Gascoin, Olivier Baud, Emmanuelle Caldagues, Stéphanie Rouleau, Audrey Migraine Bouvagnet, Régis Coutant |
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| Přispěvatelé: | Coutant, Regis, Néonatalogie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre hospitalier universitaire de Nantes (CHU Nantes), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Geneva [Switzerland], Université Paris Diderot - Paris 7 (UPD7), Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré], Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
genetic structures Physiology Maternal Health [SDV]Life Sciences [q-bio] lcsh:Medicine Weight Gain medicine.disease_cause Biochemistry Pediatrics Hypoglycemia/complications Fats Endocrinology 0302 clinical medicine Pregnancy Risk Factors Medicine and Health Sciences 030212 general & internal medicine lcsh:Science 2. Zero hunger 030219 obstetrics & reproductive medicine Multidisciplinary ddc:618 Obstetrics Obstetrics and Gynecology Gestational age Hyperinsulinism/complications Lipids Blood Sugar Transient Hyperinsulinism Body Fluids 3. Good health Gestational diabetes Blood Physiological Parameters Alimentation et Nutrition Female Anatomy Research Article Adult medicine.medical_specialty Endocrine Disorders Birth weight Pédiatrie Mothers Hypoglycemia Blood Plasma 03 medical and health sciences Hyperinsulinism Diabetes Mellitus medicine Humans Food and Nutrition Neonatology Gestational Diabetes Hyperinsulinemic hypoglycemia business.industry Body Weight lcsh:R Infant Newborn Biology and Life Sciences Neonates Infant weight-gain glucose-metabolism energy-expenditure bisphenol-a life-style pregnancy Maternal Nutritional Physiological Phenomena medicine.disease Newborn Metabolic Disorders Case-Control Studies Women's Health lcsh:Q business Developmental Biology |
| Zdroj: | Plos One 5 (13), e0195383. (2018) PLOS ONE, Vol. 13, No 5 (2018) P. e0195383 PLoS ONE, Vol 13, Iss 5, p e0195383 (2018) PLoS ONE PLoS ONE, Public Library of Science, 2018, 13 (5), pp.e0195383. ⟨10.1371/journal.pone.0195383⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; OBJECTIVE: The objective was to determine whether maternal nutritional factors are associated with transient neonatal hyperinsulinism (HI).DESIGN AND SETTING: Case control study in 4 French tertiary Obstetrics and Neonatology Departments between 2008 and 2015.METHODS: Sixty-seven mothers of neonates diagnosed with transient hyperinsulinism and 113 mothers of controls were included. The screening for hyperinsulinemic hypoglycemia in neonates was performed because of clinical symptoms suggestive of hypoglycemia or in the presence of conventional risk factors (small-for-gestational-age, prematurity, anoxo-ischemia, hypothermia, macrosomia, gestational diabetes). Hyperinsulinemic hypoglycemia was confirmed in the HI neonates and ruled out in the controls. This allowed for comparing maternal nutrition in cases and controls in a context of similar risk factors. One to 2 mothers of control neonates were included per case, and a food frequency questionnaire was addressed to the mothers between day 5 and day 10 after the birth of their newborn.RESULTS: Crude odds ratio showed that maternal weight gain, abnormal fetal rate, C-section, gender, consumption of fresh cooked vegetables, fresh fruits and fruit juices, low fat diary products, light fat products, and daily bread were significantly associated with hyperinsulinism. Maternal body mass index, hypertension, gestational diabetes, birth weight percentile, gestational age and 5-minute Apgar score were not related to HI. In a multiple backward logistic regression model, consumption of fresh cooked vegetable ≥1/day (OR = 0.33 [0.14-0.77]) and light-fat products ≥1/week (OR = 0.24 [0.08-0.71]) was protective against hyperinsulinism, whereas gestational weight gain >20 kg (OR = 9.5 [2.0-45.5]) and between 15-20 kg (OR = 4.0 [1.2-14.0]), abnormal fetal heart rate (OR = 4.4 [1.6-12.0]), and C-section (OR = 3.4 [1.3-8.9]) were risk factors.CONCLUSIONS: A diet rich in fresh cooked vegetable and reduced in fat, together with the avoidance of a high gestational weight gain may be protective against transient neonatal hyperinsulinism. |
| Databáze: | OpenAIRE |
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