A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy–entropy compensation
| Autor: | Mikhail V. Rekharsky, Tadashi Mori, Angel E. Kaifer, Simin Liu, Kimoon Kim, Michael K. Gilson, Narayanan Selvapalam, Yoshihisa Inoue, Young Ho Ko, David Sobransingh, Wei Chen, Sarvin Moghaddam, Lyle Isaacs, Hyunuk Kim, Cheng Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Streptavidin
Bridged-Ring Compounds Models Molecular Stereochemistry Entropy Supramolecular chemistry Molecular Conformation Biotin Calorimetry Crystallography X-Ray chemistry.chemical_compound Cucurbituril Molecule Biotinylation Multidisciplinary biology Molecular Structure Hydrogen bond Imidazoles Hydrogen Bonding Biological Sciences Avidin Crystallography Chemistry Kinetics Enthalpy–entropy compensation Ferrocene chemistry biology.protein Thermodynamics |
| Popis: | The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution. The equilibrium association constant for this host-guest pair is 3 × 10 15 M −1 ( K d = 3 × 10 −16 M), equivalent to that exhibited by the avidin–biotin pair. Although purely synthetic systems with larger association constants have been reported, the present one is unique because it does not rely on polyvalency. Instead, it achieves its extreme affinity by overcoming the compensatory enthalpy–entropy relationship usually observed in supramolecular complexes. Its disproportionately low entropic cost is traced to extensive host desolvation and to the rigidity of both the host and the guest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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