Current methods to diagnose small airway disease in patients with COPD
| Autor: | Don D. Sin, Hao Hang Chen, David A. Ngan, Fernando Sergio Leitao Filho, Miranda Kirby, Anthony Tam |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty Pathology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Plethysmograph In patient Total airway resistance COPD Lung medicine.diagnostic_test business.industry Small airways Public Health Environmental and Occupational Health respiratory system medicine.disease respiratory tract diseases Airway disease medicine.anatomical_structure 030228 respiratory system Cardiology business |
| Zdroj: | Expert Review of Respiratory Medicine. 10:417-429 |
| ISSN: | 1747-6356 1747-6348 |
| Popis: | The small airways are characterized by an internal diameter < 2 mm and absence of cartilage. Approximately 10–25% of total airway resistance in healthy lungs is due to the small airways, with their contribution to total airway resistance increasing substantially in chronic obstructive pulmonary disease (COPD). As the small airways are located in the lung periphery, they are not easily evaluable, which can potentially interfere with the diagnosis (especially at early stages), monitoring, detection of responses to clinical interventions, and prognostic evaluation in COPD. Here, we will discuss the currently available methods in clinical practice to evaluate small airway disease in COPD, focusing on the concept, advantages, and disadvantages of each method. |
| Databáze: | OpenAIRE |
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