Plasma and intraprostatic concentrations of ertapenem following preoperative single dose administration: a single-centre prospective experience and clinical implications—the ERTAPRO study
| Autor: | Marc-Olivier Timsit, Saik Urien, Alexandre Amin, Philippe Bourget, Alexandre Lalli, Thao Nguyen-Khoa, Charles Dariane, Constance Michel, Jean-Marc Tréluyer, Arnaud Mejean, Thomas Le Guilchet, Olivier Lortholary, Claudia De Toma |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Ertapenem Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Adolescent Urinary system 030106 microbiology Urology Microbial Sensitivity Tests beta-Lactams Preoperative care Group B Plasma Young Adult 03 medical and health sciences chemistry.chemical_compound Pharmacokinetics Tandem Mass Spectrometry Prostate Preoperative Care polycyclic compounds Humans Medicine Pharmacology (medical) Antibiotic prophylaxis Aged Aged 80 and over business.industry Incidence (epidemiology) General Medicine Antibiotic Prophylaxis Middle Aged Anti-Bacterial Agents Surgery Infectious Diseases medicine.anatomical_structure chemistry Administration Intravenous business Chromatography Liquid |
| Zdroj: | International Journal of Antimicrobial Agents. 48:168-174 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2016.04.027 |
| Popis: | The incidence of urinary tract infections caused by extended-spectrum β-lactamase (ESBL)-producing pathogens is increasing. These infections are associated with a long hospital stay in patients undergoing urological procedures. We aimed to demonstrate that significant intraprostatic diffusion of ertapenem is achieved after a single preoperative administration. A referred sample of 19 patients requiring surgery for benign prostatic hyperplasia was prospectively included. Patients received a 1 g intravenous (i.v.) dose of ertapenem 1 h (n = 10, group A) or 12 h (n = 9, group B) before blood and prostatic samples were collected. Plasma and intraprostatic concentrations of ertapenem were measured using LC-MS/MS. Intraprostatic concentrations were considered satisfactory when higher than the MIC90 value of urinary-targeted pathogens perioperatively and for 40% of the dosing interval. The Wilcoxon test and a pharmacokinetic predictive model were used. Median plasma concentrations of ertapenem were 144.3 mg/L (95% CI 126.5-157.9) in group A and 30.7 mg/L (95% CI 22.9-36.4) in group B (P |
| Databáze: | OpenAIRE |
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