Insulin Effect on Renal Sodium Reabsorption in Adolescent Offspring of Essential Hypertensive Parents
| Autor: | R Simsolo, L. Rabinovich, M Gimenez, M. Balzaretti, B Grunfeld, M. Romo |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Fractional excretion of sodium Adolescent Lithium (medication) medicine.medical_treatment Sodium Radioimmunoassay chemistry.chemical_element Lithium Kidney Essential hypertension Kidney Tubules Proximal Excretion Child of Impaired Parents Lithium Carbonate Internal medicine Internal Medicine medicine Hyperinsulinemia Humans Insulin Infusions Intravenous Renal sodium reabsorption business.industry Spectrophotometry Atomic Glucose Tolerance Test medicine.disease Glucose Endocrinology chemistry Hypertension business medicine.drug |
| Zdroj: | Hypertension. 26:1089-1092 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.26.6.1089 |
| Popis: | Abstract We previously showed that children and adolescent offspring of patients with essential hypertension have an increased proximal renal sodium reabsorption as measured by lithium fractional excretion. Insulin has been shown to have antinatriuretic properties and to be increased (hyperinsulinemia) in essential hypertension. The aim of this study was to evaluate the role of insulin on the increased proximal renal sodium reabsorption previously reported. Lithium and sodium fractional excretions were measured 3 hours before and 3 hours after an intravenous glucose tolerance test in 20 normotensive adolescents with a family history of essential hypertension (F+, 14.8±0.5 years) and 10 normotensive control subjects without a family history of hypertension (F−, 15.2±0.9 years). Results are mean±SEM. Lithium fractional excretion before glucose loading was 16.1±1.8% in F+ versus 23.5±2.0% in F− ( P P =NS). Lithium fractional excretion did not change after intravenous glucose loading in either group. The insulin area under the curve was 2815±499 in F+ versus 2290±418 μU/mL per hour in F− ( P =NS). There was no correlation between lithium fractional excretion and insulin area under the curve. Fractional excretion of sodium before glucose loading was 0.99±0.1% in F+ versus 0.99±0.1% in F− ( P =NS) and after glucose loading was 0.77±0.1 in F+ versus 0.85+0.1% in F− ( P |
| Databáze: | OpenAIRE |
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