Decreased antioxidant vitamin concentration may be a risk factor for recurrent carotid stenosis
| Autor: | Bernard Lee, R.J. Hannon, Julie A. Reid, Chee V. Soong, Ian S. Young, Louis L. Lau |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment Tocopherols Carotid endarterectomy Ascorbic Acid 030204 cardiovascular system & hematology Gastroenterology Antioxidants Statistics Nonparametric 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Restenosis Recurrence Risk Factors Internal medicine medicine Humans Carotid Stenosis Risk factor Chromatography High Pressure Liquid Endarterectomy Aged Ultrasonography Analysis of Variance Endarterectomy Carotid Vitamin C business.industry Vascular disease Incidence General Medicine Middle Aged medicine.disease Surgery Stenosis chemistry Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Vascular and endovascular surgery. 41(4) |
| ISSN: | 1538-5744 |
| Popis: | Carotid endarterectomy has been found to be associated with a transient increase in systemic oxidative stress, and this has been shown to be a predictor of restenosis. The aim of this study was to determine the incidence of early recurrent stenosis and investigate a possible role of oxidative stress in its development by measuring the concentration of antioxidant vitamins. Patients undergoing carotid endarterectomy between August 2001 and February 2003 were included in the study. A preoperative blood sample was analyzed for antioxidant vitamin concentrations. All patients were followed up by duplex scans 3 and 12 months postoperatively. Ninety-three patients (101 carotid endarterectomies) were recruited. Nine arteries had developed restenosis by 12 months. Those patients who developed recurrent stenosis had significantly lower vitamin C concentrations (19.10 ± 3.69 vs 30.11 ± 19.10, P = .02) than those who did not. This study suggests that low antioxidant vitamin levels may predispose to early restenosis after carotid endarterectomy. |
| Databáze: | OpenAIRE |
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