Are vitamin D deficiency and VDR gene polymorphisms associated with high blood pressure as defined by the ACC/AHA 2017 criteria in postmenopausal women?
| Autor: | Thaís Rasia da Silva, Karen Oppermann, Lucas Bandeira Marchesan, Gislaine Krolow Casanova, Betânia Rodrigues dos Santos, Poli Mara Spritzer |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Vitamin medicine.medical_specialty Prevalence Calcitriol receptor General Biochemistry Genetics and Molecular Biology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polymorphism (computer science) Internal medicine Genotype medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Aged Polymorphism Genetic 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology American Heart Association Vitamins Middle Aged Vitamin D Deficiency medicine.disease United States Postmenopause Cross-Sectional Studies Endocrinology Blood pressure chemistry Hypertension Receptors Calcitriol Female business Brazil |
| Zdroj: | Maturitas. 149:26-33 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/j.maturitas.2021.05.004 |
| Popis: | To assess the vitamin D levels, prevalence of vitamin D deficiency and genotypes of Fok-I, Bsm-I, Apa-I and Taq-I polymorphisms in the VDR gene and to determine whether vitamin D deficiency and VDR gene variants are associated with blood pressure levels and systemic arterial hypertension as defined by the 2017 ACC/AHA criteria.A cross-sectional study of biobanked blood samples from 339 postmenopausal women.Blood pressure strata were defined according to the 2017 ACC/AHA cutoffs. Circulating 25(OH)D levels were considered deficient if20 ng/mL.Mean serum total 25(OH)D levels were 22.99 ± 8.54 ng/mL, and 40.1% of participants were deficient in vitamin D. Overall, 7.7% had elevated blood pressure, 36.6% had stage 1 and 37.8% had stage 2 hypertension. Mean total (p = 0.014) and free 25(OH)D levels (p = 0.029) were lower in women with stage 2 hypertension than in those with normal blood pressure. A higher prevalence rate of stage 2 hypertension was associated with age (PR 1.058; 95%CI 1.033-1.083; p 0.001), BMI (PR 1.046; 95%CI 1.025-1.068; p 0.001), vitamin D deficiency (PR 1.333; 95%CI 1.016-1.749; p = 0.038) and Taq-I polymorphism (PR 1.764; 95%CI 1.030-3.019; p = 0.039). Women with vitamin D deficiency and the AA+AG genotype of Taq-I polymorphism were 33% and 76% more likely to have stage 2 hypertension, respectively, but these associations lost significance when adjusted for age and BMI.The results suggest that vitamin D deficiency and Taq-I polymorphism are associated with stage 2 hypertension, depending on age and BMI, in postmenopausal women. |
| Databáze: | OpenAIRE |
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