Deafferentation in thalamic and pontine areas in severe traumatic brain injury

Autor: Salma Mesmoudi, M. Laouchedi, Arnaud Messé, Damien Galanaud, F. Oulebsir Boumghar, Habib Benali, Louis Puybasset, Christine Delmaire, Sara Fernandez-Vidal, Mélanie Pélégrini-Issac, Vincent Perlbarg
Přispěvatelé: Université des Sciences et de la Technologie Houari Boumediene [Alger] (USTHB), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Services de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipement d'excellence MATRICE, Université Paris 1 Panthéon-Sorbonne (UP1), Laboratoire d'Imagerie Biomédicale (LIB), Johns Hopkins University School of Medicine [Baltimore], Colliot, Olivier, Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger] (USTHB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale [Paris] (LIB)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[INFO.INFO-IM] Computer Science [cs]/Medical Imaging
Diffuse Axonal Injury
Reticular formation
MESH: Magnetic Resonance Imaging
[INFO.INFO-CV] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV]
Thalamus
Pons
MESH: Child
MESH: DNA-Directed DNA Polymerase
Medicine
MESH: Aged
MESH: Middle Aged
Radiological and Ultrasound Technology
MESH: Infant
Newborn
Minimally conscious state
MESH: Mitochondrial Diseases
White Matter
MESH: Infant
MESH: Reproducibility of Results
Diffusion Tensor Imaging
[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV]
MESH: Young Adult
Anesthesia
[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV]
Biomarker (medicine)
Female
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Tractography
Adult
MESH: Mutation
Traumatic brain injury
MESH: Mitochondria
Sensitivity and Specificity
Image Interpretation
Computer-Assisted
MESH: Electroencephalography
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Radiology
Nuclear Medicine and imaging
[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
MESH: Adolescent
MESH: Humans
business.industry
MESH: Alleles
MESH: Child
Preschool
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Reproducibility of Results
[INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV]
MESH: Adult
MESH: Electrodiagnosis
medicine.disease
MESH: Central Nervous System Diseases
MESH: Male
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
nervous system
Neurology (clinical)
business
MESH: Female
Diffusion MRI
Zdroj: Journal de Neuroradiologie / Journal of Neuroradiology
Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2015, 42 (4), pp.202-11
Journal de Neuroradiologie / Journal of Neuroradiology, 2015, 42 (4), pp.202-11
ISSN: 0150-9861
Popis: International audience; Severe traumatic brain injury (TBI) is characterized mainly by diffuse axonal injuries (DAI). The cortico-subcortical disconnections induced by such fiber disruption play a central role in consciousness recovery. We hypothesized that these cortico-subcortical deafferentations inferred from diffusion MRI data could differentiate between TBI patients with favorable or unfavorable (death, vegetative state, or minimally conscious state) outcome one year after injury. Cortico-subcortical fiber density maps were derived by using probabilistic tractography from diffusion tensor imaging data acquired in 24 severe TBI patients and 9 healthy controls. These maps were compared between patients and controls as well as between patients with favorable (FO) and unfavorable (UFO) 1-year outcome to identify the thalamo-cortical and ponto-thalamo-cortical pathways involved in the maintenance of consciousness. Thalamo-cortical and ponto-thalamo-cortical fiber density was significantly lower in TBI patients than in healthy controls. Comparing FO and UFO TBI patients showed thalamo-cortical deafferentation associated with unfavorable outcome for projections from ventral posterior and intermediate thalamic nuclei to the associative frontal, sensorimotor and associative temporal cortices. Specific ponto-thalamic deafferentation in projections from the upper dorsal pons (including the reticular formation) was also associated with unfavorable outcome. Fiber density of cortico-subcortical pathways as measured from diffusion MRI tractography is a relevant candidate biomarker for early prediction of one-year favorable outcome in severe TBI.
Databáze: OpenAIRE
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