Depression and anxious apprehension distinguish frontocingulate cortical activity during top-down attentional control
| Autor: | Jeffrey M. Spielberg, Marie T. Banich, Anna S. Engels, Wendy Heller, David N. Towers, Jennifer L. Stewart, Sarah M. Sass, Rebecca L. Silton, J. Christopher Edgar, Gregory A. Miller, Bradley P. Sutton |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cingulate cortex Adolescent Anxiety Gyrus Cinguli behavioral disciplines and activities Brain mapping Article Neural Pathways Image Processing Computer-Assisted Reaction Time medicine Humans Attention Evoked Potentials Biological Psychiatry Anterior cingulate cortex Brain Mapping medicine.diagnostic_test Depression Attentional control Magnetic Resonance Imaging Frontal Lobe Dorsolateral prefrontal cortex Clinical Psychology Psychiatry and Mental health medicine.anatomical_structure Frontal lobe Stroop Test Female Functional magnetic resonance imaging Psychology Neuroscience psychological phenomena and processes Stroop effect |
| Zdroj: | Journal of Abnormal Psychology. 120:272-285 |
| ISSN: | 1939-1846 0021-843X |
| DOI: | 10.1037/a0023204 |
| Popis: | A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color-word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300-440 ms) and dACC (520-680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control. |
| Databáze: | OpenAIRE |
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