Leukocytic endogenous mediator in Crohn's disease
| Autor: | Charles O. Elson, Irwin H. Rosenberg, Noel W. Solomons, Robert A. Jacob, H H Sandstead, R S Pekarek |
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| Rok vydání: | 1978 |
| Předmět: |
Adult
Male Adolescent Immunology Disease Microbiology Enteritis Crohn Disease Leukocytes Medicine Humans Crohn's disease Crohn disease business.industry Blood Proteins Endogenous mediator Middle Aged medicine.disease Blood proteins Zinc Infectious Diseases Granulomatous colitis Parasitology Female business Research Article |
| Zdroj: | Infection and immunity. 22(3) |
| ISSN: | 0019-9567 |
| Popis: | Crohn's disease isanidiopathic inflammatory disease thatinvolves thelarge intestine (granulomatous colitis), thesmallintestine (regional enteritis), orboth(granulomatous ileocolitis). A widerangeofnutritional disorders, including zincdeficiency (7,13,16), havebeenassociated withCrohn's disease. Reduced levels ofcirculatingzinc(7,13,16), decreased hairzinc(16), defective tasteacuity (16), anda growth response tozincsupplementation ingrowth-retarded adolescents (7,13)havebeenreported. Theconcept thatplasma orserumzinclevels always reflect total bodyzinc nutriture hasbeen challenged byrecent inquiries intotheprotein binding andredistribution ofcirculating zinc in humans. Parisi andVallee (8)andHenkin(5) havereported that30to40%ofzincinthe plasma isfirmly boundtoa2-macroglobulins and |
| Databáze: | OpenAIRE |
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