Poststreptococcal acute glomerulonephritis in a girl with renal cell carcinoma: possible pathophysiological association
Autor: | Takashi Oda, Ryoko Suzuki, Hiroko Fukushima, Hidetoshi Takada, Asako Kageyama, Michio Nagata, Atsushi Iwabuchi, Kouji Masumoto, Joichi Usui |
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Rok vydání: | 2020 |
Předmět: |
Nephrology
medicine.medical_specialty Pathology Adolescent Paraneoplastic Syndromes medicine.medical_treatment 030232 urology & nephrology Renal function Case Report 030204 cardiovascular system & hematology Nephrectomy Severity of Illness Index 03 medical and health sciences Glomerulonephritis 0302 clinical medicine Renal cell carcinoma Streptococcal Infections Internal medicine medicine Carcinoma Humans Renal Insufficiency Leukocytosis Carcinoma Renal Cell Pathological business.industry Cancer General Medicine medicine.disease Kidney Neoplasms Treatment Outcome Acute Disease Female medicine.symptom business |
Zdroj: | CEN Case Rep |
ISSN: | 2192-4449 |
Popis: | The severity of the poststreptococcal acute glomerulonephritis is considered to be modulated by the immune response of each individual, although there had been few reports regarding specific factors. Renal cell carcinoma is a cancer frequently associated with paraneoplastic syndrome, characterized by fever, leukocytosis, elevated cytokines, and elevated hormone levels. All of these symptoms resolve after tumor resection. A girl with renal cell carcinoma developed renal failure rapidly, which resolved promptly right after nephrectomy for the carcinoma. She was diagnosed as having poststreptococcal acute glomerulonephritis according to the results of pathological and serological examinations. In addition, elevated serum interleukin-6 level before the surgery was detected. Six and a half years after the diagnosis, the patient's renal function was within normal range and she was tumor free. Because of the quick resolution of her renal dysfunction after the nephrectomy, paraneoplastic syndrome induced by renal cell carcinoma seemed to play a key role in the accentuation of poststreptococcal acute glomerulonephritis. |
Databáze: | OpenAIRE |
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