Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model
| Autor: | Turgay Deprem, Oğuz Merhan, Sadık Yayla, Yavuz Günerhan, Barlas Sulu, Tülay Diken Allahverdi, Sevil Atalay Vural, Neşet Köksal, Ertuğrul Allahverdi |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Alpha-Lipoic Acid Rat model Tissue Adhesions Peritoneal Diseases Gastroenterology Antioxidants Caecum chemistry.chemical_compound Malondialdehyde Laparotomy Internal medicine medicine Animals Infusions Parenteral Rats Wistar Cecum Thioctic Acid biology business.industry Glutathione Adhesion biology.organism_classification Rats Surgery Disease Models Animal Anesthesiology and Pain Medicine chemistry Emergency Medicine Female business |
| Zdroj: | Turkish Journal of Trauma and Emergency Surgery. 21:9-14 |
| ISSN: | 1307-7945 1306-696X |
| DOI: | 10.5505/tjtes.2015.15985 |
| Popis: | BACKGROUND This study was performed to determine the effect of alpha lipoic acid, a powerful antioxidant, on intra-abdominal adhesion formation. METHODS Twenty-four female Wistar Albino rats weighing 250-300 g were used in this study conducted on three groups consisting of the alpha lipoic acid group (Group I, n=8), control group (Group II, n=8), and sham group (Group III, n=8). After performing laparotomy with a midline incision under general anesthesia, the adhesion model was created on the antimesenteric side of the caecum in Group I and Group II. 50 mg/kg alpha-lipoic acid was administered intraperitoneally (IP) in Group I while the surgical procedure was performed but no drugs administered in Group II. Only laparotomy was performed in Group III. Rats were sacrificed at the end of the tenth day. RESULTS Macroscopic scoring was performed, tissue samples were obtained and subjected to biochemical and histopathological evaluation. The degree of adhesion and malondialdehyde level decreased (p |
| Databáze: | OpenAIRE |
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