The spectrum of myelodysplastic syndromes post-solid organ transplantation: A single institutional experience
| Autor: | Bachir Alobeid, JG Mears, Govind Bhagat, M. Menes, Christian E. Keller, Vundavalli V. Murty, E.K. Ho, Efsevia Vakiani, D. Diuguid, Adriana I. Colovai, Gwen Nichols |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Biopsy medicine.medical_treatment Population Myelodysplastic syndromes Azathioprine Organ transplantation Cytogenetics Postoperative Complications Bone Marrow Internal medicine hemic and lymphatic diseases medicine Humans Cumulative incidence education Retrospective Studies education.field_of_study Acute myeloid leukemia business.industry Incidence Incidence (epidemiology) Immunosuppression Organ Transplantation Hematology Middle Aged medicine.disease Transplantation Transplantation of organs tissues etc Oncology Leukemia Myeloid Female business medicine.drug |
| DOI: | 10.7916/d8-7fr2-sa61 |
| Popis: | An increased incidence of acute myeloid leukemia (AML) has recently been documented in patients post-solid organ transplantation but the incidence and types of myelodysplastic syndromes (MDS) occurring in this patient population are not known. We identified 5 patients (3M, 2F, age 48-64 years) who developed MDS ranging from 1.8 to 25 years (median 4.2 years) post-solid organ transplantation, only 2 patients had received azathioprine. The cumulative incidence of MDS in heart and lung transplant recipients at 15 years was 0.5% and 1.8%, respectively, which is markedly higher compared to the general population. Low-risk types of MDS predominated, 3 of 5 patients are alive (median 3.9 years) since diagnosis. Deletions of chromosome 20q, which have not been previously reported in post-transplant MDS/AML, were identified in 3 cases. Our findings expand the morphologic and cytogenetic spectrum of MDS occurring post-solid organ transplantation and suggest that mechanisms beside azathioprine toxicity might be important in disease pathogenesis. |
| Databáze: | OpenAIRE |
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