A sensitive method for the bioassay of acetylcholine
| Autor: | el-Wahed Sa, Hedayat Tolba, el-Hawary Mb, Mohamed T. Khayyal |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Physostigmine Serotonin In Vitro Techniques chemistry.chemical_compound Norepinephrine Serous Membrane Internal medicine Muscarinic acetylcholine receptor medicine Methods Bioassay Animals Pharmacology Chromatography Dose-Response Relationship Drug Chemistry Angiotensin II Stomach Acetylcholine Highly sensitive Endocrinology Creatinine Biological Assay Female Rabbits Histamine medicine.drug |
| Zdroj: | European journal of pharmacology. 25(3) |
| ISSN: | 0014-2999 |
| Popis: | A new sensitive method has been developed for the biological assay of acetylcholine using a serosal strip of the rabbit fundus. The preparation responded to the muscarinic effect of acetylcholine. It has the advantage of being highly sensitive to acetylcholine, in a dose of 0.5 ng/ml, particularly when eserinized. This sensitivity is maintained throughout the experiment and is thus at least equal to, if not more than that of other methods described. The preparation lacks rhythmic activity and shows good discrimination between different small quantities of acetylcholine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|