Microgel particles with distinct morphologies and common chemical compositions: a unified description of the responsivity to temperature and osmotic stress
| Autor: | Letizia Oddo, Ester Chiessi, Gaio Paradossi, Andrea Ruscito, Fabio Domenici, Yosra Toumia |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Polymers and Plastics Osmotic shock Bioengineering crosslinks 02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences Article osmoticpressure Biomaterials lcsh:Chemistry Responsivity drug delivery systems swelling PNIPAM lcsh:General. Including alchemy Settore CHIM/02 medicine lcsh:Inorganic chemistry Osmotic pressure lcsh:Science hydrogels Flory–Rehner Organic Chemistry technology industry and agriculture Receptor interaction drugdeliverysystems 021001 nanoscience & nanotechnology lcsh:QD146-197 0104 chemical sciences osmotic pressure Chemical engineering lcsh:QD1-999 Drug delivery Self-healing hydrogels lcsh:Q Swelling medicine.symptom 0210 nano-technology lcsh:QD1-65 |
| Zdroj: | Gels, Vol 6, Iss 34, p 34 (2020) Gels Volume 6 Issue 4 |
| Popis: | Poly(N-isopropylacrylamide) (PNIPAM) hydrogel microparticles with different core&ndash shell morphologies have been designed, while maintaining an unvaried chemical composition: a morphology with (i) an un-crosslinked core with a crosslinked shell of PNIPAM chains and (ii) PNIPAM chains crosslinked to form the core with a shell consisting of tethered un-crosslinked PNIPAM chains to the core. Both morphologies with two different degrees of crosslinking have been assessed by confocal microscopy and tested with respect to their temperature responsivity and deformation by applying an osmotic stress. The thermal and mechanical behavior of these architectures have been framed within a Flory&ndash Rehner modified model in order to describe the microgel volume shrinking occurring as response to a temperature increase or an osmotic perturbation. This study provides a background for assessing to what extent the mechanical features of the microgel particle surface affect the interactions occurring at the interface of a microgel particle with a cell, in addition to the already know ligand/receptor interaction. These results have direct implications in triggering a limited phagocytosis of microdevices designed as injectable drug delivery systems. |
| Databáze: | OpenAIRE |
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