Relationship between vascular cell adhesion molecule-1 (VCAM-1), soluble receptor for advanced glycation end products (sRAGE) and functional hemodynamic parameters of arteriovenous fistula
| Autor: | Dacian Tirinescu, Maria Ticala, Anca Laura Coman, Diana Moldovan, Alina Potra, Crina Rusu, Livia Budisan, Ina Maria Kacso, Cosmina Ioana Bondor |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Receptor for Advanced Glycation End Products 030232 urology & nephrology Vascular Cell Adhesion Molecule-1 Hemodynamics Arteriovenous fistula 030204 cardiovascular system & hematology Carotid Intima-Media Thickness 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Renal Dialysis Glycation Internal medicine medicine Humans VCAM-1 Vascular Calcification Receptor Dialysis Cell adhesion molecule business.industry medicine.disease chemistry Nephrology Arteriovenous Fistula Cardiology Surgery Hemodialysis business |
| Zdroj: | The Journal of Vascular Access. 23:67-74 |
| ISSN: | 1724-6032 1129-7298 |
| DOI: | 10.1177/1129729820976264 |
| Popis: | Background: The preferred vascular access for hemodialysis is represented by arteriovenous fistula (AVF) due to fewer complications and more prolonged survival. Considerable efforts have been made to identify biomarkers associated with AVF dysfunction, but results are conflicting. Vascular cell adhesion molecule (VCAM-1) and advanced glycation end products are involved in atherogenesis, vascular calcification, peripheral artery disease, and neointimal hyperplasia in renal and non-renal patients. The objective of this study was to evaluate whether there is an association between VCAM-1, soluble receptor for advanced glycation end products (sRAGE), NcarboxymethylLysine (CML), and arteriovenous fistula dysfunction (AVF). Methods: VCAM-1, sRAGE, and CML were performed using the ELISA technique in 88 HD patients. Ultrasound assessment of AVF reports brachial artery blood flow (Qa), brachial resistivity index (RI), presence of calcification, and the diameter. AVF dysfunction was defined as a brachial artery Qa ⩽ 500 ml/min or RI ⩾ 0.5. Results: The median level of VCAM-1 [2676.5(2206.8–4203.9) versus 2613.2(1885.7–3161.8), p 0.026] was significantly higher in patients with AVF dysfunction compared to the rest of the patients. sRAGE and CML were higher in this group but without statistical significance. In patients with AVF dysfunction, significant positive correlations were found between VCAM-1and sRAGE ( r = 0.417, p = 0.001), RI ( r = 0.313, p = 0.046), dialysis vintage ( r = 0.540, p Conclusion: The results we obtained showed that patients with AVF dysfunction had a significantly higher level of VCAM-l. A positive correlation between VCAM-1 and sRAGE was identified in this group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|