Bacterial siderophores: synthesis and biological activities of novel pyochelin analogues

Autor:	Franc Pattus, Isabelle J. Schalk, Adel Zamri, Mohamed A. Abdallah
Přispěvatelé:	Schalk, Isabelle, Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Rok vydání:	2003
Předmět:	Siderophore Magnetic Resonance Spectroscopy Stereochemistry Iron Clinical Biochemistry Siderophores MESH: Thiazoles Pharmaceutical Science Iron Chelating Agents 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Chemical synthesis MESH: Phenols Phenols Drug Discovery [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology medicine [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology MESH: Siderophores Molecular Biology MESH: Iron biology MESH: Magnetic Resonance Spectroscopy 010405 organic chemistry Chemistry Pseudomonas aeruginosa Organic Chemistry MESH: Indicators and Reagents Biological activity General Medicine biology.organism_classification 3. Good health 0104 chemical sciences Thiazoles 010404 medicinal & biomolecular chemistry MESH: Iron Chelating Agents MESH: Pseudomonas aeruginosa Pseudomonadales Molecular Medicine Indicators and Reagents Enantiomer Bacteria Pseudomonadaceae
Zdroj:	Bioorganic and Medicinal Chemistry Letters Bioorganic and Medicinal Chemistry Letters, Elsevier, 2003, 13 (6), pp.1147-50
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00010-6
Popis:	The synthesis and biological activities of four pyochelin analogues substituted in different parts of the molecule are reported: 5-NHBoc-pyochelin, 3"N-Boc-pyochelin, 3"-nor-NH-pyochelin and neopyochelin II, the enantiomer of natural pyochelin. All these compounds complex iron(III) and transport it at different rates into the cells of Pseudomonas aeruginosa.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e73112f80aaef9e25e1389a1b2f17e https://doi.org/10.1016/s0960-894x(03)00010-6 Zobrazit plný text záznamu Full Text from ScienceDirect