The Cardioprotective Effects of Aminoguanidine on Lipopolysaccharide Induced Inflammation in Rats
| Autor: | Farimah Beheshti, Mahmoud Hosseini, Milad Hashemzehi, Maryam Mahmoudabady, Mohammad Reza Hadipanah |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Male Lipopolysaccharide Anti-Inflammatory Agents Nitric Oxide Synthase Type II Inflammation 030204 cardiovascular system & hematology Pharmacology Nitric Oxide Toxicology medicine.disease_cause Cardiovascular System Guanidines Antioxidants Nitric oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Enzyme Inhibitors Rats Wistar Molecular Biology biology Interleukin Malondialdehyde Cardiotoxicity Disease Models Animal Oxidative Stress chemistry Cardiovascular Diseases Catalase 030220 oncology & carcinogenesis biology.protein Inflammation Mediators medicine.symptom Cardiology and Cardiovascular Medicine Oxidative stress |
| Zdroj: | Cardiovascular Toxicology. 20:474-481 |
| ISSN: | 1559-0259 1530-7905 |
| Popis: | Myocardial dysfunction, a major component of sepsis-induced multiorgan failure, contributes to the production of massive amounts of pro-inflammatory cytokines. Nitric oxide (NO) is known to act as a precursor of free radicals in inflammation. This research was conducted to assess the effect of aminoguanidine (AG) on lipopolysaccharide (LPS)-induced heart injury. 50 male rats were categorized into five groups (n = 10): (1) control, (2) LPS, (3) LPS-AG50, (4) LPS-AG100, and (5) LPS-AG150. LPS (1 mg/kg) was injected for 5 weeks, and AG (50, 100 and 150 mg/kg) was injected 30 min prior to LPS administration. All drugs were injected intraperitoneally. LPS-evolved cardiovascular toxicity was indicated by the augmentation in the level of nitric oxide (NO) metabolites, interleukin (IL)-6 and malondialdehyde (MDA), as well as reduced contents of total thiol groups, catalase (CAT), and superoxide dismutase (SOD) activity in serum, heart, and aortic tissues. In AG treated groups, noxious effects of LPS were not observed in the serum and harvested tissues. AG reduced MDA, NO metabolites, and IL- 6 and increased total thiol, CAT, and SOD activity in the heart, aorta and serum. As an inhibitor of inducible NO synthase (iNOS), AG further reduced LPS-induced oxidative stress and inflammation, hence considered as cardioprotective. |
| Databáze: | OpenAIRE |
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