Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy
| Autor: | N. T. J. O'connor, J. S. Wainscoat, Harald Stein, Brunangelo Falini, J.A. Crick, K C Gatter, D Y Mason |
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| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty T-Lymphocytes T cell Receptors Antigen T-Cell Immunoglobulins Biology Lymphocyte Activation Pathology and Forensic Medicine Antigen medicine Humans T-cell lymphoma Cytotoxic T cell T-cell receptor General Medicine medicine.disease medicine.anatomical_structure Immunoblastic Lymphadenopathy T-Cell Receptor Gene Monoclonal Cancer research biology.protein Antibody Cell Division Research Article |
| Zdroj: | Journal of Clinical Pathology. 39:1229-1232 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.39.11.1229 |
| Popis: | The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma. |
| Databáze: | OpenAIRE |
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