Retinal microglia polarization in diabetic retinopathy
| Autor: | Yue Yuan, Xin Li, Xin-Yuan Gao, Hui-Yao Li, Hong-Yu Kuang, Zi-Wei Yu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology medicine.medical_treatment Central nervous system Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system medicine Diabetes Mellitus Humans Neuroinflammation Diabetic Retinopathy Microglia business.industry Neurodegeneration Retinal Diabetic retinopathy medicine.disease Sensory Systems 030104 developmental biology Cytokine medicine.anatomical_structure chemistry business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Visual neuroscience. 38 |
| ISSN: | 1469-8714 |
| Popis: | Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|