Nigerian surgical outcomes – Report of a 7-day prospective cohort study and external validation of the African surgical outcomes study surgical risk calculator

Autor: Yunus Olorode, Mark Edubio, Olusola Idowu, Luka Samuel, Shanka Buba, Stella Eguma, Tonia C Onyeka, Elizabeth Ogboli-Nwasor, Ibironke Desalu, Ibrahim Bala Salisu, S D Amanor-Boadu, Oluwabunmi Fatungase, Olubusola Alagbe-Briggs, Suleiman Ado, Rabiu Mohammed, Chris Nwokorie, Olanrewaju N. Akanmu, Abdulrahman Aliyu, Bisola Onajin-Obembe, Alhassan Datti Mohammed, Folayemi Faponle, Olanrewaju Olubukola Oyedepo, Kodilinye Izuora, Yakubu Adinoyi, Olugbenga Akinwonmi, Garba Hamza, Nigerian Surgical Outcomes Study Investigators, Omobolaji O. Ayandipo, Edith Agu, Erdoo Isamade, Onochie Nweze, Michael Efu, Abiodun Jasper, Mamuda Atiku, Ahmed Nuhu, B B Osinaike, Chimaobi Nnaji, Felicia Asudo, Richard Ewah, I Akhideno, Abdulrahman Mohammed
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Surgery. 68:148-156
ISSN: 1743-9191
DOI: 10.1016/j.ijsu.2019.06.003
Popis: Background Surgical outcomes study for individual nations remains important because of international differences in patterns of surgical disease. We aimed to contribute to data on post-operative complications, critical care admissions and mortality following elective surgery in Nigeria and also validate the African Surgical Outcomes Study (ASOS) surgical risk calculator in our adult patient cohort. Materials and methods We conducted a 7-day, national prospective observational cohort study in consented consecutive patients undergoing elective surgery with a planned overnight hospital stay following elective surgery during a seven-day study period. The outcome measures were in-hospital postoperative complications, critical care admissions and in-hospital mortality censored at 30 days. Also, we identified variables which significantly contributed to higher ASOS surgical risk score. External validation was performed using area under the receiver operating characteristic curve (ROC) for discrimination assessment and Hosmer–Lemeshow test for calibration. Results A total of 1,425 patients from 79 hospitals participated in the study. Postoperative complications occurred in 264(18.5%, 95% CI 16.6–20.6), 20(7.6%) of whom were admitted into the ICU and 16(6.0%) did not survive. Total ICU admission was 57 (4%), with mortality rate of 23.5% following planned admission and overall in-hospital death was 22(1.5%, 95% CI 0.9–2.2). All prognostic factors in the ASOS risk calculator were significantly associated with higher ASOS score and the scoring system showed moderate discrimination (0⋅73, 95% CI 0.62–0.83). Hosmer–Lemeshow χ2 test revealed scale was well calibrated in the validation cohort. Conclusion NiSOS validates the findings of ASOS and the ability of the ASOS surgical risk calculator to predict risk of developing severe postoperative complications and mortality. We identified failure-to-rescue as a problem in Nigeria. Furthermore, this study has provided policy makers with benchmarks that can be used to monitor programmes aimed at reducing the morbidity and mortality after elective surgery. We recommend the adoption of the ASOS surgical risk calculator as a tool for risk stratification preoperatively for elective surgery.
Databáze: OpenAIRE
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