Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis
| Autor: | Shuang Li, Ji-guo Yu, Jun Zhang, Shuqiong Hu, Yi Xiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Subgroup analysis Polymorphism Single Nucleotide 03 medical and health sciences Macular Degeneration 0302 clinical medicine Gene Frequency lcsh:Ophthalmology Polymorphism (computer science) Internal medicine Age related Genetic variation medicine Humans Genetic Predisposition to Disease Allele Polymorphism Alleles Genetic Association Studies business.industry Age-related macular degeneration Genetic variants Genetic Variation General Medicine Complement C3 Macular degeneration medicine.disease Ophthalmology Meta-analysis 030104 developmental biology C3 gene lcsh:RE1-994 030221 ophthalmology & optometry business Research Article |
| Zdroj: | BMC Ophthalmology, Vol 18, Iss 1, Pp 1-14 (2018) BMC Ophthalmology |
| ISSN: | 1471-2415 |
| Popis: | Background The purpose of this study is to discuss whether genetic variants (rs2230199, rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of advanced AMD. Methods We performed a meta-analysis using electronic databases to search relevant articles. A total of 40 case-control studies from 38 available articles (20,673 cases and 20,025 controls) were included in our study. Results In our meta-analysis, the pooled results showed that the carriage of G allele for rs2230199 and the T allele for rs1047286 had a tendency to the risk of advanced AMD (OR = 1.49, 95% CI = 1.39–1.59, P |
| Databáze: | OpenAIRE |
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