Predictors of behaviour in solitary fibrous tumours of the pleura surgically resected: Analysis of 107 patients
| Autor: | Fiorella Calabrese, Pia Ferrigno, Cristiano Breda, Federica Pezzuto, Stefano Terzi, Federico Rea, Giuseppe Marulli, Alice Bellini, Claudia Brombin, Fabio Lo Giudice, Ivan Lomangino, Licia Laurino |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty recurrence Multivariate analysis Parietal Pleura Pleural Neoplasms Young Adult 03 medical and health sciences 0302 clinical medicine Median follow-up 80 and over Humans Medicine fibroma prognostic factors prognostic scores solitary fibrous tumour Aged Aged 80 and over Female Follow-Up Studies Middle Aged Neoplasm Recurrence Local Prognosis Retrospective Studies Solitary Fibrous Tumors Survival Rate business.industry Solitary fibrous tumour Retrospective cohort study Histology General Medicine medicine.disease Neoplasm Recurrence Local Oncology 030220 oncology & carcinogenesis Population study 030211 gastroenterology & hepatology Surgery Radiology Fibroma business |
| Zdroj: | Journal of Surgical Oncology. |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | Objectives Gold standard therapy for solitary fibrous tumour of the pleura is complete surgical resection. Aims of this retrospective study are to evaluate oncological and surgical outcomes and to verify the clinical reliability of prognostic scores presented in literature. Methods Study population: 107 patients surgically treated between 1972 and 2018. Male/female ratio: 1/2.45; median age at surgery: 60 years (range, 19-80); peduncle lesions 69.8%; visceral pleura origin 72.9%; benign histology 73.8%; median diameter 8 cm (range 1 to 35, 27 cases giant [≥15 cm]). Results After a median follow up of 7 years, 12 patients had recurrence. By multivariate analysis, malignant histology (P = .03; HR, 4.17; 95% CI, 1.15-15.06), origin from parietal pleura (P = .03; HR, 3.90; 95% CI, 1.08-14.09), England (P = .002; HR, 1.98; 95% CI, 1.28-3.07), Diebold (P = .008; HR, 1.96; 95% CI, 1.20-3.22) and Tapias (P = .003; HR, 1.75; 95% CI, 1.20-2.53) scores were found independent significant predictors of relapse. Giant tumours were associated with open surgery (P = .003), origin from parietal pleura (P = .011) and intraoperative bleeding (P > .001). Overall 10-year disease-free survival (DFS) rate was 81%. Predictors of worst DFS were parietal pleura origin (P = .002), malignant histology (P = .006) and all the prognostic scores. Conclusions Malignant histology and origin from parietal pleura were significant predictors of tumour recurrence and worst DFS. The use of current scoring systems can help to predict clinical behaviour. Patients with higher risk of relapse can benefit from closer follow up, prolonged over 10 years. |
| Databáze: | OpenAIRE |
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