Philadelphia chromosome (Ph) positive chronic myelocytic leukemia (CML): frequency of additional findings
| Autor: | Hans-Dietrich Bruhn, Elisabeth Gödde-Salz, Norbert Schmitz |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Adolescent Ph Positive Chromosomal translocation Biology Philadelphia chromosome Y chromosome Gastroenterology Translocation Genetic Internal medicine Genetics medicine Chromosomes Human 21-22 and Y Humans Molecular Biology Aged Cytogenetics Karyotype Middle Aged medicine.disease Chromosome Banding medicine.anatomical_structure Leukemia Myeloid Karyotyping Myelocytic leukemia Female Bone marrow |
| Zdroj: | Cancer genetics and cytogenetics. 14(3-4) |
| ISSN: | 0165-4608 |
| Popis: | This article documents the cytogenetic findings in 79 patients with typical Ph-positive chronic myelocytic leukemia (CML). Direct preparations of bone marrow and/or peripheral blood of 46 males and 33 females were studied with different banding techniques. Seventy patients were studied during chronic phase. Three (4.3%) had unusual or complex translocations: t(6;22)(p21;q11), t(8;12;9;22)(p21;q21;q34;q11), and t(9;11;22)(q34;q13;q11). One (1.4%) had a +Ph, 1 (1.4%) had a +8, 1 (1.4%) had a del(3)(p13,p23), and 4 of 30 males (13.3%) showed loss of Y chromosome. Five of 8 cases studied during blast crisis had additional abnormalities. The +8 occurred in 4 cases, +10 and +19 each in 3 cases, +6, + 9q+, and +13 each in 2 cases, and +5, +11, +14, +21, +Ph, i(17q), dic(1;9), and structural abnormalities of chromosomes #1, #5, #12, and #13 each in 1 case. Two cases studied in blast crisis alone had complex translocations leading to the Ph. Because it cannot be ruled out that these translocations are secondary, they were not included in the calculation of the frequency of atypical translocations. |
| Databáze: | OpenAIRE |
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