Normocalcaemic, vitamin D‐sufficient hyperparathyroidism – high prevalence and low morbidity in the general population: A long‐term follow‐up study, the WHO MONICA project, Gothenburg, Sweden
| Autor: | Göran Oleröd, Georgios Kontogeorgos, Penelope Trimpou, Kerstin Landin-Wilhelmsen, Christine M. Laine, Anders Lindahl |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypercalcaemia Cross-sectional study Endocrinology Diabetes and Metabolism Population Myocardial Infarction Bone and Bones Body Mass Index Endocrinology Internal medicine Electric Impedance Prevalence medicine Vitamin D and neurology Humans Vitamin D education Stroke Aged Sweden education.field_of_study Hyperparathyroidism Anthropometry business.industry Middle Aged medicine.disease Editor's Choice Cross-Sectional Studies Hypertension Hypercalcemia Regression Analysis Calcium Female Thyroid function business Body mass index Rapid Communication Follow-Up Studies |
| Zdroj: | Clinical Endocrinology |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/cen.12819 |
| Popis: | SummaryObjective There is limited knowledge about the natural history of normocalcaemic, vitamin D-sufficient hyperparathyroidism (nHPT). The aim was to study the prevalence of nHPT and its relation to morbidity. Design Cross-sectional and retrospective study at the Sahlgrenska University Hospital, Gothenburg, Sweden. Subjects A random population of 608 men and women, age 25–64 years, was studied in 1995 as part of the WHO MONICA study and reinvestigated in 2008 (n = 410, of whom 277 were vitamin D sufficient). Measurements A serum intact parathyroid hormone (S-PTH) ≥60 ng/l was considered as HPT, S-calcium 2·15–2·49 mmol/l as normocalcaemia and S-25(OH)D ≥ 50 nmol/l as vitamin D sufficiency. Data on fractures, stroke and myocardial infarction were retrieved until 2013, that is a 17-year follow-up. Results The prevalence of nHPT was 2·0% in 1995 (age 25–64) and 11·0% in 2008 (age 38–79). S-PTH was positively correlated with age and BMI. After adjustment for these variables, a high S-PTH level (≥60 ng/l) at follow-up was associated with previously low S-25(OH)D, high osteocalcin, S-PTH and both past and presently treated hypertension. No relation was seen with creatinine, cystatin C, malabsorption markers, thyroid function, glucose, insulin, lipids, calcaneal quantitative ultrasound, fractures, myocardial infarction, stroke or death at follow-up. Conclusions This small random population study showed that nHPT was common, 11% at follow-up. Only one individual developed mild hypercalcaemia in 13 years. Previous S-PTH was predictive of nHPT and hypertension was prevalent, but no increase in hard end-points was seen over a 17-year period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text